脂肪组织特异性胰岛素抵抗与动脉样硬化斑块和社区人口中的负担之间的关联
Qi Zhou1,2, Xueli Cai3,4, Aoming Jin5,6
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, q.zhou@mail.ccmu.edu.cn.
Neuroepidemiology
|July 28, 2024
概括
在非糖尿病成年人中,脂肪组织中的胰岛素抵抗与动脉硬化和大脑和心脏中的斑块积累有关. 这一发现突显了一般人群中心血管疾病的关键风险因素.
科学领域:
- 心血管医学 心血管医学
- 代谢综合征是代谢综合征的一种.
- 医疗成像医学成像
背景情况:
- 在没有糖尿病的个体中调查脂肪组织特异性胰岛素抵抗和动脉样硬化之间的联系.
- 了解社区群体内内,外和冠状动脉中动脉硬化斑块的流行情况.
研究的目的:
- 确定脂肪组织特异性胰岛素抵抗与动脉样硬化斑块负担之间的关联.
- 为了评估这种关联在内,外和冠状动脉.
主要方法:
- 从禁食血清胰岛素和自由脂肪酸计算脂肪组织特异性胰岛素抵抗指数 (Adipo-IR).
- 使用3.0 T MRI对内/外动脉和CT血管学对冠状动脉评估斑块.
- 使用后勤回归模型来分析Adipo-IR四分位数和动脉样硬化负担之间的关系.
主要成果:
- 在2,719名参与者中,内,外和冠状动脉斑块的患病率分别为15.9%,35.9%和42.7%.
- 与最低四分位数相比,Adipo-IR的最高四分位数显示内动脉样硬化负担 (cOR: 1.35) 和冠状动脉斑块 (OR: 1.45) 的几率增加.
- 在较高的Adipo-IR和增加的冠状动脉段狭窄得分之间发现了显著的关联 (cOR: 1.44).
结论:
- 脂肪组织特异性胰岛素耐药性与动脉样硬化负担和斑块存在显著相关.
- 这些发现表明,胰岛素抵抗和动脉样硬化在内和冠状动脉之间存在联系.
- 这种关联在非糖尿病人的社区群体中观察到.
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