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All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
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在光子或质子辐射后,正常出现的白质结构的扩散减少表明区域辐射敏感性的差异.

Katharina Witzmann1, Felix Raschke1, Tim Wesemann2

  • 1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology - OncoRay, Dresden, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

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PubMed
概括
此摘要是机器生成的。

放射治疗导致大脑白质微观结构的变化,可通过扩散张力成像 (DTI) 检测到. 这些扩散张力成像 (DTI) 对正常白质 (WM) 的变化取决于辐射剂量和治疗后的时间.

关键词:
扩散张力成像成像技术磁共振成像技术 磁共振成像技术主要的大脑瘤主要是脑瘤.质子束辐射辐射的辐射.白物质的结构是白物质的结构.

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科学领域:

  • 神经成像是一种神经成像.
  • 辐射瘤学 辐射瘤学
  • 医学物理 医学物理

背景情况:

  • 放射化疗 (RCT) 是质瘤患者的标准治疗方法.
  • 无线电脑试验使周围看起来正常 (NA) 的脑组织暴露在辐射中.
  • 磁共振成像 (MRI) 与扩散张力成像 (DTI) 可以评估放射治疗对大脑微观结构的影响.

研究的目的:

  • 为了分析放射治疗后白质 (WM) 结构的区域DTI变化.
  • 为了确定这些DTI变化的剂量和时间依赖性.

主要方法:

  • 长度前性研究 (NCT02824731) 涉及23名用质子或光子束疗法治疗的质瘤患者.
  • 在辐射后3个月间隔到36个月获得的MRI数据.
  • 在15个WM结构中使用多变量线性回归分析平均,辐射和轴向扩散率 (MD,RD,AD) 和分数异构性 (FA).

主要成果:

  • 在RCT后,在四个WM结构 (内部囊,冠状辐射,后部乳头辐射,上部纵向囊) 中观察到显著下降的RD和MD.
  • 后部乳头辐射显示出最明显的变化 (ΔRD = -8.51%, ΔMD = -6.14%).
  • DTI变化显著依赖于平均辐射剂量和随访时间.

结论:

  • 即使在低辐射剂量下,也检测到WM亚结构的显著DTI变化.
  • 调查结果表明,可能存在新的辐射剂量限制,以避免易受伤害的WM结构.
  • 这可能有助于减轻质瘤患者治疗相关的副作用.