作为研究工具的非传统模型:未走过的道路
1Department of Drug Discovery and Biomedical Sciences, College of Pharmacy and Peromyscus Genetic Stock Center, University of South Carolina, Columbia, SC, USA.
Trends in molecular medicine
|July 28, 2024
概括
在生物医学研究中Mus musculus的广泛使用源于历史上的便利性,而不是独特的疾病相关性. 扩大研究模式超越传统的研究模式对于推动健康科学发现至关重要.
科学领域:
- 生物医学研究生物医学研究
- 翻译科学 翻译科学
- 动物模型 动物模型
背景情况:
- 历史因素导致生物医学研究中主要使用少数物种,特别是Mus musculus.
- 这种依赖是由于先前存在的资源和工具,而不是对人类疾病建模的固有适用性.
- 目前的研究轨迹受到这些传统模型的局限性限制.
研究的目的:
- 分析生物医学研究中选择主流动物模型的历史基础.
- 突出传统模型狭窄范围所带来的局限性.
- 倡导扩大非传统研究模式,以促进科学进步.
主要方法:
- 对动物模型选择的历史趋势的文献综述.
- 分析资源的可用性及其对模式采用的影响.
- 对传统与非传统模型在人类疾病研究中的实用性进行比较评估.
主要成果:
- 选择Mus musculus作为主要研究模型的动机是工具和资源的历史可用性.
- 肌肉与特定的人类疾病的相关性并不是其广泛使用的主要驱动因素.
- 生物医学研究的进展受到目前使用的模型范围有限的显著限制.
结论:
- 持续依赖有限的一组传统动物模型限制了生物医学研究重大突破的潜力.
- 扩大非传统研究模式的利用和多样性对于提高科学发现的临床相关性至关重要.
- 更广泛地采用新型模型是必要的,以克服历史悠久的研究对象固有的局限性.
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