糖尿病对持续放射性异常和COVID-19幸存者的肺扩散功能障碍的影响:为期3年的前性队列研究
Linxia Wu1, Xiaoyu Han1, Lu Chen2
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, The People's Republic of China (L.W., X.H., Y.L., T.N., F.W., X.Z., H.S., C.Z.); Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, The People's Republic of China (L.W., X.H., Y.L., T.N., F.W., X.Z., H.S., C.Z.).
糖尿病显著恶化COVID-19幸存者的长期肺功能障碍,导致更多的呼吸系统症状和异常. 这凸显了糖尿病COVID-19康复患者持续肺部监测的必要性.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病是严重的COVID-19结果的已知危险因素.
- 糖尿病对COVID-19后肺部恢复的长期影响尚不清楚.
研究的目的:
- 评估糖尿病对持续放射性肺部异常和COVID-19幸存者的肺功能障碍的三年影响.
主要方法:
- 一个前性的多中心队列研究,比较COVID-19幸存者与没有糖尿病.
- 系列胸部CT扫描,症状问卷和肺功能测试在出院后的6个月,1年,2年和3年进行.
- 分析了3年随访期肺功能障碍的独立预测因素.
主要成果:
- 患有糖尿病的COVID-19幸存者在3年后表现出更高的呼吸系统症状,放射性肺异常和肺扩散功能障碍.
- 糖尿病,女性性别,严重的COVID-19,过敏和纤维状CT变化是肺扩散功能障碍的独立预测因素.
结论:
- 糖尿病对COVID-19幸存者的肺部健康有显著的长期有害影响.
- 证据支持长期监测COVID-19幸存者患有糖尿病的肺部异常.
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