在肥胖的人群中,提氨酸状态和编码肠道提氨酸载体和转录因子的基因
Oguzhan Sıtkı Dizdar1, Serife Erdem2, Elif Dilek Deliktas3
1Department of Internal Medicine and Clinical Nutrition Unit, Kayseri City Training and Research Hospital, University of Health Sciences, Kayseri, Turkey; Department of Medical Biology and Genome and Stem Cell Center (GENKOK) Faculty of Medicine, Erciyes University, Kayseri, Turkey.
概括
肥胖个体表现出更高的血胺水平,尽管饮食摄入量较低. 胺转运体SLC19A2的基因表达与肥胖和血胺度有关,这表明它在营养状况中起着作用.
科学领域:
- 营养生物化学 营养生物化学
- 分子生物学分子生物学
- 肥胖问题研究研究
背景情况:
- 有不一致的数据存在关于在肥胖人口中的胺状况.
- 肥胖可能会影响肠道吸收和运输必需的营养物质,如胺.
- 了解胺载体基因表达对于评估肥胖症中的营养状况至关重要.
研究的目的:
- 为了确定肥胖患者的胺状况.
- 为了研究SLC19A2和SLC19A3基因的表达,这些基因编码着胺转运体.
- 检查 Sp1 转录因子与胺状态和基因表达有关的作用.
主要方法:
- 这是一项涉及35名肥胖成年人和11名健康对照者的横截面研究.
- 在小肠上皮细胞中对SLC19A2/3基因表达的定量RT-PCR分析.
- 使用液体染色学-双重质谱法测量全血中胺总量的测量.
- 通过食物频率调查问卷评估每日胺和能量摄入量.
主要成果:
- 与对照组相比,肥胖患者的每日胺摄入量显著降低,但全血胺水平较高.
- 在体质指数 (BMI) 和全血胺水平之间观察到正相关性.
- 在BMI≥35kg/m2的个体中,SLC19A2基因表达较低,并且与血胺水平呈正相关性.
结论:
- 在肠道胺吸收和血液中胺总水平之间存在潜在的关联.
- 高亲和膜胺转运体的转录调节,特别是SLC19A2,可能会影响这种关系.
- 这些发现突出了肥胖,胺运输和营养状况之间的复杂相互作用.
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