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糖尿病患者的临床眼表面特征和MUC5AC表达:基于人口的研究

Zijie Fang¹, Ke Liu¹, Emmanuel Eric Pazo¹

¹Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.

Eye (London, England)

|July 28, 2024

概括

患有干眼病的糖尿病患者显示MUC5AC的表达减少,结膜杯细胞减少. 较高的HbA1c水平与糖尿病患者干眼的眼膜度增加相关.

科学领域:

眼科医生眼科眼科
内分泌学在内分泌学.
生物医学科学生物医学科学

背景情况:

干眼病 (DED) 是一种普遍影响眼表面健康的疾病.
糖尿病被越来越多地认为是DED的危险因素.
了解连接糖尿病和DED的具体机制对于有效管理至关重要.

研究的目的:

为了比较患有和没有DED的糖尿病和非糖尿病个体的临床特征和粘素5AC (MUC5AC) 表达.
评估糖尿病患者的血糖控制和干眼参数之间的关系.

主要方法:

399名参与者 (50-80岁) 的队列被分为四组:没有DED的非糖尿病人,没有DED的非糖尿病人,没有DED的糖尿病人和患有DED的糖尿病人.
收集的数据包括人口统计数据,禁食血葡萄糖,HbA1c,眼睛表面疾病指数 (OSDI),干眼症状,眼透光,梅博姆腺评估,眼MUC5AC表达和结膜杯细胞密度 (GCD).

主要成果:

与DED的非糖尿病人相比,患有DED的糖尿病人表现出明显更高的角膜和结膜染色分数.
眼MUC5AC度和GCD在糖尿病DED组与非糖尿病DED组相比显著较低.
糖尿病患者的HbA1c水平较高 (≥7.8%) 与膜透度 (TFO) 的增加以及撕裂时间的缩短有关.

结论:

患有DED的糖尿病患者有更严重的眼睛表面损伤.
在糖尿病患者中观察到结膜杯细胞和MUC5AC表达的显著减少,特别是那些患有DED的患者.
糖尿病患者TFO升高与糖尿病持续时间和血糖控制 (HbA1c) 有关.

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