含有草油作为透增强剂的洛诺西卡姆乳液的配方和特征
Vibha Kumari1, Meenakshi Bajpai1
1Institute of Pharmaceutical Research, GLA University, Uttar Pradesh, Mathura, 281406, India.
概括
这项研究开发了一种优化的乳化剂配方,用于防水药物洛诺西卡姆. 新的乳化剂系统证明了药物释放和稳定性的改善,与传统配方相比,它提供了更可行的通过皮肤递送选择.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 乳液是一种先进的透皮药物输送系统,结合了乳液和凝.
- 它为像洛诺西卡姆这样的疏水药物提供了潜在的替代品.
- 目前的洛诺西卡姆配方可能不适合局部治疗.
研究的目的:
- 制定和优化一种乳化剂,用于通过皮肤递送洛诺西卡姆.
- 评估开发的emul.gel的物理化学特性和体外药物释放.
- 将乳化剂配方的疗效与现有的洛诺西卡姆输送系统进行比较.
主要方法:
- 洛诺西卡姆溶解性研究指导了表面活性剂和辅表面活性剂的选择.
- 制备了乳液,并将其纳入不同度的碳醇934凝基中.
- 配方通过使用弗朗茨扩散细胞进行了物理性质,药物含量和体外释放的评估.
主要成果:
- 优化的乳化剂配方 (F3) 表现出可接受的物理特性,包括均性,可扩散性和可挤出性.
- 在体外释放研究表明,在6小时内,F3配方释放了83%的洛诺西卡姆.
- 在测试条件下,乳化剂配方表现出良好的稳定性.
结论:
- 乳是一种可行且有效的通过皮肤递送药物系统,用于像洛诺西卡姆这样的疏水性药物.
- 优化的乳化剂配方提供了可控释放,适合在诸如类风湿性关节炎等疾病中局部应用.
- 这种先进的剂量形式比传统的药片,囊和注射配方更有前途.
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