心血管健康从子宫开始
Bonita Falkner1,2, Barbara T Alexander3, Anne-Monique Nuyt4
1Departments of Medicine (B.F.), Sydney Kimmel College of Medicine, Thomas Jefferson University, Philadelphia, PA.
Hypertension (Dallas, Tex. : 1979)
|July 29, 2024
概括
儿童高血压现在已经得到认可,自20世纪70年代以来,定义一直在发展. 研究将早期生活因素,如低出生体重,与成人心血管疾病风险联系起来.
科学领域:
- 心血管科学 心血管科学
- 儿科健康 儿科健康
- 流行病学 流行病学
背景情况:
- 高血压在历史上被认为是一种成人疾病,儿童的血压 (BP) 不经常测量.
- 儿童高血压水平低于成人,随年龄和成长而异,需要不同的高血压定义.
- 儿童和青少年血压水平的第95百分位成为高血压的流行病学定义.
研究的目的:
- 审查最近关于与心血管疾病风险相关的母亲和后代疾病的发现.
- 探索高血压的童年起源,建立在巴克假设的基础上.
- 检查从纵向母婴队列和实验模型的数据.
主要方法:
- 纵向母婴队列研究的综述.
- 对研究心血管疾病起源的实验模型的分析.
- 关于儿童高血压和风险因素的流行病学和临床研究.
主要成果:
- 儿童血压水平与年龄和成长有关,需要具体的定义.
- 已经确定了儿童高血压的危险因素,将青少年血压与成人高血压联系起来.
- 巴克假设强调了低出生体重与成人心血管疾病的联系.
结论:
- 了解高血压的儿童起源对于预防成人心血管疾病至关重要.
- 在发育过程中,母亲和后代的状况显著影响未来的心血管健康.
- 对母婴健康和实验模型的持续研究对于预防心血管疾病至关重要.
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