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Updated: Jun 11, 2026

Nanomanipulation of Single RNA Molecules by Optical Tweezers
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在单个分子水平上量化DNA毛针的微秒溶液相 conformational 动力学

Alexander K Foote1, Kunihiko Ishii2,3, Brendan Cullinane1

  • 1Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

ACS physical chemistry Au
|July 29, 2024
PubMed
概括

这项研究量化了使用单分子抗布罗恩电动力学 (ABEL) 捕获的DNA发针动态. 该方法揭示了快速的结构变化和潜在的分子异质性,进步了我们对生物分子机制的理解.

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¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...