慢性疼痛和抑郁症对阿片类药物使用障碍治疗药物的影响:混合方法分析
相关实验视频
Updated: Jun 18, 2025

07:08
Burn Injury-Induced Pain and Depression-Like Behavior in Mice
Published on: September 29, 2021
3.1K
Corinne N Kacmarek1, Hannah C Smith2, Maxwell Kuehn3
1US Department of Veterans Affairs Mental Illness Research Education and Clinical Center, Baltimore, MD, USA.
Heroin addiction and related clinical problems
|July 29, 2024
概括
治疗阿片类药物使用障碍 (MOUD) 治疗中的治疗疼痛和抑郁症可以改善患者的治疗结果. 整合心理和身体健康支持可以提高阿片类药物使用障碍 (OUD) 的保留和戒断.
科学领域:
- 成 药物 药物 药物 药物
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 阿片类药物使用障碍 (OUD) 带来了重大的健康挑战,阿片类药物使用障碍 (MOUD) 治疗药物的保留率有所变化.
- 了解影响MOUD治疗参与和成功的因素对于改善患者的治疗结果至关重要.
研究的目的:
- 调查同时出现的抑郁症和身体疼痛对治疗结果的影响,对于接受阿片类药物使用障碍 (MOUD) 药物治疗的阿片类药物使用障碍 (OUD) 患者.
- 在OUD和MOUD治疗的背景下,探索患者与疼痛和抑郁症的经验.
主要方法:
- 采用混合方法方法,将疼痛,抑郁和治疗结果的定量评估与定性访谈相结合.
- 参与者 (N=50) 从城市成治疗中心招募,接受布普伦诺芬或甲.
- 统计分析包括相关性分析,后勤回归和费舍尔精确测试,以及面试的主题分析.
主要成果:
- 高龄与更高的90天治疗参与度相关.
- 抑郁症得分升高与90天随访时的阿片类药物尿液分析呈阳性相关.
- 定性数据揭示了患者的慢性疼痛和抑郁的经历,以及对综合护理的渴望.
结论:
- 在MOUD期间解决身体疼痛和心理健康问题的综合治疗对于改善患者体验至关重要.
- 解决这些并发症有可能提高治疗的持续性,并促进戒断阿片类药物.
相关概念视频
Analgesia and Pain Management
557
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
557
Opioid Analgesics: Synthetic and Semisynthetic Opioids
260
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
260
Stress and Mental Health
94
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
94
Opioid Analgesics: Morphine and Other Natural Cogeners
210
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
210
Depressants
106
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
106
Antidepressant Drugs: MAOIs and Other Agents
209
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
209

