针对LDL胆固醇的进展:PCSK9抑制剂及其他方面
Maya Safarova1, Tia Bimal2, Daniel E Soffer3
1Division of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI USA.
American journal of preventive cardiology
|July 29, 2024
概括
降低低密度脂蛋白胆固醇 (LDL-C) 对心血管健康至关重要. 本综述探讨了非他类药物治疗方法,以控制高高的LDL-C,并在他类药物不足时降低动脉样硬化心血管疾病 (ASCVD) 风险.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 遗传学 遗传学 是一个
背景情况:
- 在一生中,低密度脂蛋白胆固醇 (LDL-C) 的升高与心血管事件直接相关.
- 类他类药物对降低LDL-C的基础,但全球目标的实现仍然不够理想.
- 对于非他类药物治疗来管理残留ASCVD风险,存在重大未满足的需求.
研究的目的:
- 审查除了他类药物之外的药物治疗选择,以降低LDL-C.
- 引导医生使用这些疗法来降低ASCVD风险.
- 根据疗效,安全性和结果提供考虑非他类药物治疗的算法.
主要方法:
- 审查目前和试验中用于降低LDL-C的药物治疗方法.
- 对非他类药物干预的治疗指南的分析.
- 探索新的机制,包括基因编辑和PCSK9抑制剂.
主要成果:
- 有多种非他类药物治疗方法 (ezetimibe,PCSK9抑制剂,inclisiran,bempedoic acid) 可供使用.
- 对于同卵性家族性高胆固醇血症,已有先进的治疗方法 (洛米塔皮德,埃维纳库马布).
- 诸如CETP抑制剂和基因编辑等研究中的治疗方法对未来充满希望.
结论:
- 非他类药物治疗对于实现LDL-C目标和降低残留ASCVD风险至关重要.
- 这些药物的指导性选择对于最佳的患者结果至关重要.
- 新兴疗法为管理高脂血症和预防心血管事件提供了新的途径.
更多相关视频
相关概念视频
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
613
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
613
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Cholesterol: Significance and Regulation
524
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
524
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
505
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
505
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
152
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
152
Lipids: Dietary Sources and Requirements
715
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
715


