牛奶中的雌激素成分泽拉,含量和检测方法; 一个系统的审查和元分析
Kiandokht Ghanati1, Burhan Basaran2, Amirhossein Abedini3
1Department of food science and Technology, National Nutrition and Food Technology Research Institute (NNFTRI) and Food safety research center, Shahid Beheshti University of medical sciences, Tehran, Iran.
Toxicology reports
|July 29, 2024
概括
泽拉伦 (ZEN) 是一种具有雌激素作用的真菌毒素,在59%的牛奶样本中发现. 它的存在,即使是少量,也会扰乱内分泌腺,需要定期监测乳制品.
科学领域:
- 食品安全和毒理学
- 内分泌学 在内分泌学.
- 兽医公共卫生 兽医公共卫生
背景情况:
- 泽拉 (ZEN) 和其代谢产物具有雌激素特性,可以污染牛奶.
- 这些真菌毒素有可能破坏内分泌腺功能.
研究的目的:
- 系统地审查和估计牛奶中ZEN及其代谢物的含量.
- 确定共同的分析方法并评估污染的流行程度.
主要方法:
- 使用关键词进行系统的文献搜索:zearalenone,ZEN,牛奶,反动物的牛奶,牛奶,乳制品,乳制品.
- 从最初的946个手稿中对17个选定的手稿进行了审查.
- 使用综合元分析 (CMA) 软件进行元分析,包括元回归和子组分析.
主要成果:
- 在分析的研究中,在59%的研究中检测到ZEN.
- 常见的分析技术包括UHPLC,HPLC和ELISA.
- 经过元分析,估计牛奶中ZEN的总污染量为0.036±0.017μg/L.
- 观察到显著的异质性,测量方法被确定为来源.
结论:
- 牛奶中ZEN污染很普遍,并由于其内分泌干扰潜力而构成风险.
- 由于没有允许的极限,因此需要定期监测.
- 有效的分析方法对于控制牛奶和乳制品中的ZEN及其代谢物至关重要.
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