以前存在的睡眠障碍和COVID-19的风险:一个元分析
Jiawei Zhou1, Xia Li1, Ting Zhang1
1Department of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, China.
EClinicalMedicine
|July 29, 2024
概括
预先存在的睡眠障碍,如阻塞性睡眠呼吸暂停,增加了COVID-19的风险,包括易感性,住院,死亡率和长期COVID. 年龄和性别显著影响这些结果.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 睡眠医学 睡眠医学
背景情况:
- 睡眠障碍是普遍存在的,但往往是COVID-19的低估风险因素.
- 调查预先存在的睡眠问题对COVID-19结果的影响至关重要.
研究的目的:
- 分析预先存在的睡眠障碍与COVID-19易感性之间的关联.
- 评估睡眠障碍对COVID-19严重程度和长期后果 (长期COVID) 的影响.
主要方法:
- 一项对48项观察性研究 (n=8,664,026) 的系统综述和元分析.
- 搜索了PubMed,科学网和Embase数据库,直到2024年5月.
- 为各种睡眠障碍和COVID-19结果计算了聚合几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 睡眠障碍显著增加了COVID-19易感性 (OR=1.12),住院 (OR=1.25),死亡率 (OR=1.45) 和长期COVID (OR=1.36) 的风险.
- 阻塞性睡眠呼吸暂停 (OSA),异常睡眠时间和夜班工作与增加易感性和住院治疗有关.
- OSA与更高的死亡率有关,而OSA,异常睡眠时间和失眠增加了长期COVID的风险.
结论:
- 预先存在的睡眠障碍,特别是OSA,是COVID-19不良结果的重要风险因素.
- 年龄和性别调节睡眠障碍和COVID-19之间的关系,年轻人表现出更高的易感性/住院治疗,男性死亡率更高.
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