在头部和部状细胞癌的II-IV级部解剖中节点收益率
João V Pinto1,2,3, Sofia Pedrosa4, Fernando Vales1,2
1Otorhinolaryngology Department, Unidade Local de Saúde de São João, Porto, PRT.
Cureus
|July 29, 2024
概括
在部剖析中,下节点产量与先前的放射治疗和外节点入侵有关,但与生存结果无关. 这一发现对于理解选择性部剖析的有效性至关重要.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 手术瘤学手术瘤学
- 头部和部癌症研究研究
背景情况:
- 选择性部剖析 (ND) 是分期和治疗头癌的一个关键程序.
- 在II-IV级ND中优化节点产量对于准确的分期和治疗计划至关重要.
- 影响节点产量的因素及其对患者存活率的影响需要进一步调查.
研究的目的:
- 在II-IV级选择性部剖析 (NDs) 中识别与节点产量相关的因素.
- 评估结节产量对无病生存期 (DFS) 和经过NDs的患者的整体生存期 (OS) 的影响.
主要方法:
- 进行了一项观察性回顾性研究.
- 包括2015年1月至2021年12月期间接受II-IV级ND的成年患者.
- 分析了患者的人口统计,治疗史和瘤学结果.
主要成果:
- 总共分析了44名患者和78名不确定病例.
- 下节点产量与先前的放射治疗 (p=0.042) 和外节点入侵 (p<0.001) 有显著的关联.
- 在对cN状态和年龄进行调整后,节点收益率与五年DFS (p=0.681) 或OS (p=0.888) 没有显著的关联.
结论:
- 在II-IV级ND的节点产量减少与之前的放射治疗和节外延伸有显著的相关性.
- 这些剖析中的节点产量似乎不会影响长期无病或整体存活率.
- 这些发现强调了在选择性部剖析中解释节点产量时考虑特定患者因素的重要性.
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