皮肤透肝胆道排水 (PTBD) 后恶性胆道阻塞患者的化疗改善了生存率
Vikas K Jagtap1, Sumit Kumar1, Caleb Harris2
1Radiation Oncology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
Cureus
|July 29, 2024
概括
皮肤通过肝胆道排水 (PTBD) 有效地缓解恶性胆道阻塞引起的黄. 在PTBD后接受化疗的患者与没有接受化疗的患者相比,整体存活率显著改善.
科学领域:
- 干预性放射学 干预性放射学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 恶性胆道阻塞通常会导致黄,需要息治疗.
- 皮肤通过肝胆道排水 (PTBD) 是缓解黄的标准程序.
- 在PTBD之后的化疗可能在某些特定情况下提供生存益处.
研究的目的:
- 评估PTBD在缓解恶性胆道阻塞方面的疗效.
- 评估后续化疗对接受PTBD治疗的患者生存率的影响.
主要方法:
- 在2017年3月至2023年3月期间,对43名因恶性胆道阻塞而接受PTBD治疗的患者进行了回顾性分析.
- 在PTBD后达到≤5 mg/dL胆红素水平的患者被考虑进行化疗.
- 生存分析比较了接受化疗的患者与没有接受进一步治疗的患者.
主要成果:
- 在分析的队列中,PTBD成功地缓解了阻塞.
- 16名患者 (37.2%) 对PTBD有反应,并被考虑进一步治疗.
- 在PTBD后接受化疗的患者的整体存活率 (73.3%) 与没有化疗的患者相比 (33%,p=0.008) 显著改善.
结论:
- PTBD是治疗恶性胆道阻塞和黄的有效方法.
- 很大一部分患者 (34.9%) 在PTBD后接受了进一步的针对癌症的治疗.
- 在PTBD后的化疗与恶性胆道阻塞中改善整体生存率有关.
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