相关实验视频
Updated: Apr 30, 2026

08:09
A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
Published on: June 7, 2018
9.8K
扩张性心肌病遗传学的研究景观:从文献计量分析的洞察力
Tiantian Chao1, Yaru Ge2, Jinghui Sun1
1National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Frontiers in cardiovascular medicine
|July 29, 2024
概括
这项研究分析了2013-2022年间关于扩张性心肌病 (DCM) 遗传学的4,141篇出版物. 关键的研究领域包括下一代测序,基因型-表型相关性,以及心力衰竭和突然心脏死亡风险分层的精准医学.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 生物医学研究生物医学研究
背景情况:
- 扩张性心肌病 (DCM) 是一种复杂的心肌疾病,具有多种遗传和遗传原因.
- 在了解DCM的遗传基础方面取得了重大进展.
- 绘制研究景观对于指导未来对DCM遗传学的研究至关重要.
研究的目的:
- 分析DCM遗传学主要研究工作的分布.
- 确定该领域的关键研究热点和新兴前沿.
- 为塑造DCM遗传学的未来研究方向提供见解.
主要方法:
- 2013年至2022年间发表的4141份文档的图书统计分析,来自Web of Science核心收藏.
- 分析作者,机构和国家/地区的共同作者网络.
- 检查参考文献的共同引用和关键词的共同出现,以确定研究趋势.
主要成果:
- 与DCM遗传学相关的年度出版物稳步增加.
- 主要作者 (赛德曼,梅德尔,辛纳格拉),机构 (德国心血管研究中心) 和国家 (美国,中国,德国) 的识别.
- 关键的研究集群包括DCM,层状a/c,心力衰竭,心脏突然死亡,多变心肌病,心律失常心肌病和下一代测序.
- 2019年后的新兴关键词包括节律失调性心肌病,全外体测序,RBM 20,表型,风险分层,精准医学,基因型和机器学习.
结论:
- DCM研究领域的遗传学是充满活力和不断发展的.
- 目前的热点和边界涉及通过下一代测序解密遗传特征,了解基因变异机制,并开发针对心力衰竭和突发心脏病死亡的向治疗.
- 未来的研究应该专注于基因型-表型相关性和与其他心肌病的遗传重叠.
相关概念视频
Genome-wide Association Studies-GWAS
12.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.6K
Pharmacogenomics: Identification of New Drug Targets
120
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
120
Cardiomyopathy I: Introduction and Classification
821
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
821
Cardiomyopathy II: Dilated Cardiomyopathy
790
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
790
Cardiomyopathy III: Hypertrophic Cardiomyopathy
804
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
804
Cardiomyopathy V: Interprofessional Care
753
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
753

