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Updated: Jun 18, 2025

Methyl-binding DNA capture Sequencing for Patient Tissues
08:40

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

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全表观基因组DNA甲基化协会CHIP的研究提供了对受损基因调节的洞察力

Daniel Levy1, Sara Kirmani2, Tianxiao Huan3

  • 1Framingham Heart Study, Framingham, MA, 01702, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health.

Research square
|July 29, 2024
PubMed
概括

克隆性血液形成 (CHIP) 涉及干细胞中与年龄相关的突变. 这项研究揭示了与CHIP相关的表观遗传变化,影响心血管疾病和死亡风险.

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相关概念视频

Epigenetic Regulation01:37

Epigenetic Regulation

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X-chromosome...
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Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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