通过使用FAERS数据,比较基胺和胺在性别之间的不良影响
1The Department of Anesthesiology, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
Frontiers in pharmacology
|July 29, 2024
概括
对于胺和胺胺的不良药物事件,存在基于性别的差异. 了解这些副作用的变化对于临床实践中的个性化治疗方法至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 药品安全 药品安全
背景情况:
- 乙胺,一种麻醉剂,及其S-反体,乙胺,为抑郁症提供了新的治疗选择.
- 性别之间的药理动力学和荷尔蒙状况的差异表明药物不良事件 (ADEs) 的潜在基于性别的变化.
- 这项研究旨在分析基胺和胺的性别特异性ADEs,以告知个性化的临床实践.
研究的目的:
- 调查和比较与胺酸和胺酸相关的性别特异性不良药物事件 (ADEs).
- 确定这些药物的安全性概况中的潜在基于性别的差异.
- 通过突出性别特定的ADE模式,促进个性化治疗策略.
主要方法:
- 从2004年第一季度到2023年第二季度向美国食品和药物管理局不良事件报告系统 (FAERS) 报告的药物不良反应的数据挖掘.
- 对胺和胺报告的分析,按性别分层.
- 用95%置信区间 (CI) 计算报告几率比率 (ROR),以评估特定不良事件的可能性.
主要成果:
- 分析包括2907名女性和1634名男性对胺胺的报告,以及552名女性和653名男性对胺的报告.
- 对于乙胺,男性常见的不良事件包括完成自杀,治疗产品效果降低,尿路保留和高血压.
- 对于胺,男性表现出更高的毒性风险,胸肌梗塞,囊炎和动荡,而女性更容易发生自杀念头,高胺酶水平,硬化性胆管炎和无菌性气.
结论:
- 与胺和胺相关的不良事件在性别之间表现出显著的差异.
- 临床实践应考虑这些基于性别的ADE变化,以进行个性化的患者治疗.
- 识别性别特定的安全配置文件可以优化治疗结果和患者护理.
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