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关于肠道微生物群和代谢功能障碍相关的脂肪肝炎的全球研究趋势:从文献计和科学计分析的见解
Naqash Alam1, Linying Jia1, Ao Cheng1
1Laboratory Animal Center, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Frontiers in pharmacology
|July 29, 2024
概括
这项文献计量研究揭示了对肠道微生物群和代谢功能障碍相关的脂肪肝炎 (MASH) 的日益增长的研究. 关键发现强调了肠肝轴,失生症,以及MASH治疗中针对微生物群的潜在治疗方法.
科学领域:
- 图书统计学 图书统计学
- 肝病学 肝病学是一种肝病学.
- 微生物学 微生物学
背景情况:
- 代谢功能障碍相关的脂肪肝炎 (MASH) 是一种炎症性肝病,是一种代谢功能障碍相关的脂肪性肝病 (MASLD) 的亚型.
- 在全球范围内,MASH的发病率正在增加,这引发了对其潜在机制的重大科学兴趣.
- 肠道微生物群在MASH病原发生中的作用是一个快速发展的研究领域.
研究的目的:
- 进行对肠道微生物群和MASH的研究进行全面的文献分析.
- 识别知识结构,研究热点和该领域的新兴趋势.
- 在过去十年中,在MASH中绘制肠肝轴研究的演变图.
主要方法:
- 对2014-2023年期间的文章和评论进行了对Web of Science核心集合的系统搜索.
- 通过使用VOSviewer,CiteSpace和R包"bibliometrix"进行了图书统计分析.
- 分析重点是出版趋势,有影响力的机构,作者,期刊和关键词分析,以确定研究热点.
主要成果:
- 总共分析了4,069份文件,显示了十年来出版物的显著增加,美国和中国是主要贡献者.
- 加利福尼亚大学圣地亚哥分校和研究人员罗希特·卢姆巴和尤努西·ZM被认为是高度富有成效和影响力的.
- 关键词分析揭示了关键研究领域,包括代谢综合征,胰岛素耐药性,肠肝轴,肠透性和炎症,突出了当前的热点.
结论:
- 这项研究强调了肠肝轴和肠道微生物群失生症在MASH病变发生过程中的关键作用.
- 多器官交叉是MASLD/MASH发展的一个关键方面.
- 研究结果表明,针对MASH的微生物群特异性疗法和创新的医疗保健策略有前途.
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