草通过阻断SGK1/NF-κB信号通路来抑制喘的发展
Xiufeng Chen1, Yong Hong Jiang1, Xiaoqin Fei1
1Department of Pediatrics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Journal of asthma and allergy
|July 29, 2024
概括
草是一种天然的抗炎化合物,在喘模型中有效降低呼吸道炎症和细胞损伤. 它抑制SGK1/NF-κB通路,表明其作为喘治疗治疗剂的潜力.
科学领域:
- * 药理学 药理学 药理学
- * 免疫学 免疫学
- * 细胞生物学 细胞生物学
背景情况:
- *喘是一种慢性呼吸道疾病,其特点是气道炎症,咳和喘息.
- * 草是一种天然化合物,以其抗炎性质而闻名.
- * Herbacetin在治疗喘方面的疗效尚未得到广泛研究.
研究的目的:
- * 在喘模型中研究Herbacetin的抗炎作用.
- * 探索赫巴西在喘中的作用的潜在分子机制.
- * 评估Herbacetin作为喘的潜在治疗剂.
主要方法:
- * 建立脂聚糖 (LPS) 诱导的肺上皮细胞 (BASE-2B) 和卵胺 (OVA) 诱导的喘小鼠模型.
- * 用CCK8,西布洛特和流细胞计量来评估细胞活力,增殖和亡.
- *通过HE和马森染色分析肺部组织病理学,并检测气泡泡洗液中的炎症因素.
主要成果:
- * 草素在LPS诱导的BASE-2B细胞和OVA诱导的喘小鼠中显示出抗炎作用.
- * 草素抑制了细胞亡,促进了细胞增殖,并减少了炎症标志物.
- * Herbacetin被确定为SGK1的抑制剂,抑制NF-κB/p-P65通路.
结论:
- * 草通过抑制SGK1/NF-κB通路,在喘中表现出显著的抗炎作用.
- * 草素降低了促炎性细胞因子水平,为喘提供了潜在的治疗策略.
- * 草作为一种治疗喘的新疗法具有前景.
相关概念视频
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
233
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
233
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
264
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
264
Asthma: Pathogenesis and Management
379
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
379
NF-κB-dependent Signaling Pathway
7.4K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.4K
Antiasthma Drugs: Leukotriene Modifiers
268
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
268
TGF - β Signaling Pathway
7.3K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.3K


