在慢性鼻炎的鼻粘膜中形成超硫化物
Jun Suzuki1, Tomotaka Hemmi2, Tomoaki Ida3
1Department of Otolaryngology, Head and Neck Surgery Tohoku University Graduate School of Medicine Sendai Japan.
Laryngoscope investigative otolaryngology
|July 29, 2024
概括
慢性鼻炎 (CRS) 涉及改变的硫化合物. 乙性CRS (ECRS) 显示了减少的谷氨 (GSH) 和氨酸 (CysSH),表明氧化应激和影响疾病的发病.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 氧化应激干扰与各种疾病有关.
- 像谷氨 (GSH) 和氨酸 (CysSH) 这样的硫化合物是关键的抗氧化剂.
- 超硫化物正在成为氧化应激和氧化还原信号的强有力的调节剂.
研究的目的:
- 为了研究慢性鼻炎 (CRS) 亚型中的硫化合物变化.
- 阐明超硫化物在CRS病变发生中的作用.
- 为了量化控制和CRS患者的鼻粘膜中的硫化合物.
主要方法:
- 质谱法用于测量硫化合物水平.
- 从对照个体,埃索诺菲尔CRS (ECRS) 患者和非ECRS (nECRS) 患者中分析了鼻腔粘膜样本.
- 在正常和炎症的鼻粘膜中对超硫化物进行了定量评估.
主要成果:
- 在ECRS患者中,GSH和CysSH水平显著下降.
- 在ECRS中,氧化应激的指标GSSG/GSH比率升高.
- 三硫化 (GSSSG) 是一种超硫化前体,在ECRS和nECRS患者中均降低.
结论:
- 硫化合物失调有助于CRS的病变发生.
- 这项研究提供了首次对CRS中超硫化物的定量评估.
- 这些发现突显了改变硫代谢在CRS发展中的潜在作用.
相关概念视频
Chronic Pharyngitis
1.6K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
1.6K
Cystic Fibrosis: Management
151
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
151
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
426
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
426
Cystic Fibrosis: Pathogenesis
202
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
202
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
Suctioning the Nasopharyngeal Airway
335
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
Equipment Required
335


