开放式喷雾机器人:一种高通量纸喷雾质谱平台,用于疾病查
Nancy Shyrley García-Rojas1,2, Héctor Guillén-Alonso1,3, Scott MacKay2
1Laboratorio de Análisis Bioquímico e Instrumental, Unidad de Genómica Avanzada, Cinvestav, Km. 9.6 Libramiento Norte, Carretera Irapuato-León, Irapuato, Guanajuato, México.
HardwareX
|July 29, 2024
概括
一个新的机器人平台使用纸喷雾质谱法 (PS-MS) 自动化纸质新生儿查. 这项创新简化了样品的运输,使代谢查更容易获得和更具成本效益,特别是对于偏远的人群.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 公共卫生 公共卫生
背景情况:
- 新生儿疾病查对于改善生存率和生活质量至关重要.
- 质谱法 (MS) 是一种强大的代谢查工具.
- 目前的方法在样品运输方面面临物流挑战,特别是在偏远地区.
研究的目的:
- 开发一个机器人平台,用于自动化纸喷雾质谱测量 (PS-MS).
- 为了克服与传统新生儿查样本运输相关的后勤和成本障碍.
- 为了增加代谢查的样本吞吐量.
主要方法:
- 开发"Open SprayBot"机器人平台,用于自动化样本分析.
- 使用纸喷雾 (PS) 电离技术在纸条上进行样本分析.
- 与RUMBA32和Arduino Mega板的集成,注射器,以及PS-MS操作的电源.
主要成果:
- 开放式喷雾机成功通过PS-MS自动化分析纸张存储样本.
- 通过量化palmitoyl-l-carnitine,一个关键的新生儿查生物标志物,证明了可用性.
- 该系统促进了更简单,更具成本效益的样品运输作为干燥点.
结论:
- 开放式喷雾机提供了一种简化和自动化的方法,用于使用PS-MS进行新生儿查.
- 这项技术提高了代谢查的可访问性和效率,特别是在资源有限的环境中.
- 自动化PS-MS具有显著的潜力,可以改善全球新生儿医疗保健结果.
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