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基于正念的干预对患有多发性硬化症的人的认知的影响:随机对照试验的系统审查和元分析

Alyssa Komar¹, Kirsty Dickson², Mohammad Alavinia¹

¹Department of Medicine, Division of Physical Medicine and Rehabilitation, University of Toronto, Toronto, ON, Canada.

Frontiers in psychiatry

|July 29, 2024

概括

基于正念的干预措施 (MBI) 显示了改善多发性硬化症 (PwMS) 患者认知功能的潜力. 虽然结果不一致,但MBI可能会受益于特定的认知测试,这证明了进一步的高质量研究.

科学领域:

神经科学是一个神经科学.
康复医学康复医学康复医学
心理学心理学心理学

背景情况:

认知障碍影响了多发性硬化症 (PwMS) 患者的很大一部分,影响了他们的日常生活和独立性.
基于正念的干预 (MBI) 越来越多地被作为一种非药物治疗方法来管理慢性疾病的症状.
关于MBI对PwMS认知功能的影响的现有证据需要系统的合成来指导临床实践和未来的研究.

研究的目的:

系统地审查和综合来自随机对照试验 (RCT) 关于MBIs在PwMS认知功能的疗效的证据.
对相关研究进行元分析,以量化MBI对特定认知指标的影响.

主要方法:

为了确定符合条件的RCT,进行了系统的文献搜索.
两位独立审查员根据预先定义的标准对研究进行了选,并提取了数据.
在可行的情况下,使用随机效应模型进行了元分析,并遵守PRISMA指南.

主要成果:

包括12个涉及700名PwMS的RCT. 干预的形式和内容各不相同.
五项研究 (n=254) 的元分析表明,MBI显著改善了步调听力序列加法测试 (PASAT) -2分数 (SMD=0.38).
在PASAT-3,感知缺陷问卷和符号数字模式测试上的改进在统计学上并不显著,尽管观察到一些趋势.

结论:

初步的元分析结果表明,MBI可能为PwMS的认知功能提供好处,特别是在PASAT-2.
目前的证据是不一致的,突出需要更严格,高质量的RCT.
进一步的研究是必不可少的,以确定MBI对多发性硬化症的认知增强的影响和最佳应用.

关键词:

认知功能认知功能这是一个元分析.保持正念,就是正念.多发性硬化症多发性硬化症系统性审查系统性审查

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