植物中MutS基因家族的扩展
Daniel B Sloan1, Amanda K Broz1, Shady A Kuster1,2
1Department of Biology, Colorado State University, Fort Collins, CO, USA.
bioRxiv : the preprint server for biology
|July 29, 2024
概括
MutS基因家族通过内共生基因转移和水平基因转移在植物中扩大,影响有机体遗传学. 它们的特定作用,尤其是蓝菌类基因,仍在探索中.
科学领域:
- 遗传学 是一个遗传学.
- 进化生物学 进化生物学
- 分子生物学分子生物学
背景情况:
- MutS基因家族对于DNA修复,重组和翻译在整个生命中至关重要.
- 由于独特的进化事件,植物与其他真核生物相比拥有更多的MutS基因.
- 了解这些特定于植物的MutS基因是理解植物遗传学和进化过程的关键.
研究的目的:
- 研究植物特异性MutS基因的起源和功能.
- 为了澄清 MutS 基因家族在陆地植物中的扩张的进化历史.
- 根据同类和结构预测,假设未表征的植物MutS基因的作用.
主要方法:
- 对比基因组学来追踪基因起源和重复.
- 遗传学分析以了解进化关系.
- 蛋白质结构和预测功能的生物信息分析.
主要成果:
- 在陆地植物,绿藻,红藻和绿藻中确定了类似蓝藻的MutS1和MutS2基因,可能来自塑体内共生基因转移.
- 在Viridiplantae中揭示了MutS2的重复和MSH6的古老重复成MSH6和MSH7.
- 通过横向基因转移获得MSH1,与真菌/动物MSH1.1不同.
结论:
- 在植物中,MutS基因家族的扩大,特别是与蓝藻细菌衍生基因的扩大,显著塑造了植物器官遗传学.
- 大多数植物特异性MutS蛋白都向线粒体和/或塑体,突出显示它们在有机细胞功能中的作用.
- 需要进一步的研究来描述植物MutS1和MutS2的功能,尽管在MSH1,MSH6和MSH7方面取得了进展.
关键词:
这是一种MutS同类物.生物体内共生 (endosymbiosis) 是一种生物体内共生.基因复制是基因的复制.横向基因转移是指水平基因转移.不匹配的维修 维修不匹配的维修人类的基因组学.蛋白质结构 蛋白质结构再组合的复合方式.核糖体拖延时间更多相关视频
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