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Updated: Jun 18, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

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通过蛋白质-蛋白质相互作用来调节氨酸酸酶PTP1B的度调节

Cassandra A Chartier1, Virgil A Woods2,3, Yunyao Xu1

  • 1Department of Chemistry, Columbia University, New York, NY 10027.

bioRxiv : the preprint server for biology
|July 29, 2024
PubMed
概括

适应蛋白 Grb2 的结合全osterically 增强了铁酸酶 PTP1B 的活性. 这种相互作用取决于PTP1B的富含proline的区域,改变了PTP1B的结构和功能,揭示了细胞信号传递的新调节机制.

关键词:
在Grb2中使用Grb2.这就是PTP1B.蛋白质氨酸酸酶是一种蛋白质氨酸酸酶.在SH3域名中,SH3域名是SH3域名.亚洛斯特菌是什么意思?质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量蛋白质与蛋白质的相互作用

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