动态力量驱动器官形态变化在胚胎发育期间的变化
Raj Kumar Manna1,2, Emma M Retzlaff3, Anna Maria Hinman3
1Department of Physics Syracuse University, Syracuse, NY 13244, USA.
bioRxiv : the preprint server for biology
|July 29, 2024
概括
组织运动的动力力量在胚胎发育过程中塑造器官. 对斑马鱼胚胎的实验证实,这些力量,而不仅仅是生物化学信号,对于器官形态学至关重要.
科学领域:
- 发育生物学是发展生物学.
- 生物物理学的生物物理.
- 斑马鱼的胚胎发生
背景情况:
- 器官和组织的形状对于功能至关重要.
- 生物化学信号和生物物理力量影响胚胎形态.
- 动态的作用,组织规模的力量往往被忽视.
研究的目的:
- 研究动态组织力量对器官形状的贡献.
- 模拟和实验验证这些力量在胚胎发育中的作用.
主要方法:
- 组织动态的数学建模.
- 在使用斑马鱼胚胎的体内实验中.
- 激光切除以扰乱组织力量.
主要成果:
- 模型预测显示,驱动Kupffer囊泡形状变化的动力.
- 激光切除改变了组织力量,导致器官形状的预测变化.
- 这些发现凸显了动态力量在塑造胚胎器官中的重要性.
结论:
- 由组织运动产生的动力力量是胚胎发生过程中器官塑造的关键机制.
- 这项研究表明,在发育生物学中考虑组织规模力量的重要性.
相关概念视频
Gastrulation
57.0K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
57.0K
Development of Blood Vessels
555
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
555
Morphogenesis
27.8K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
27.8K
Development of the Sexual Organs in the Embryo and Fetus
621
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
621
Cleavage and Blastulation
45.0K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
45.0K
Cellular Differentiation
2.6K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...
2.6K


