非肌肉侵入性膀癌的组织学亚型
Nicola Giudici1, Roland Seiler2,3
1Department of Urology, Spitalzentrum Biel, Biel 2501, Switzerland. nicolagiudici@gmail.com.
World journal of clinical oncology
|July 29, 2024
概括
在非肌肉侵入性膀癌 (NMIBC) 中,组织学亚型 (HS) 经常被遗漏,但表明有侵略性的疾病. 需要进一步的研究来了解NMIBC中的HS,以便制定更好的治疗策略.
科学领域:
- 尿瘤学 尿瘤学
- 病理学 病理学 病理学
- 癌症研究 癌症研究
背景情况:
- 大多数膀癌 (BCs) 是非肌肉侵入性 (NMIBC),通常是常规的泌尿腺癌 (UC).
- 在UC中的组织学亚型 (HS) 在肌肉侵入性BC (MIBC) 中被描述得很好,但在NMIBC中不太了解.
- 目前对侵袭性尿路细胞瘤的分类也适用于NMIBC的一个子集.
研究的目的:
- 为了突出NMIBC中HS的不足诊断,由于标准诊断工作的限制.
- 强调NMIBC中HS的临床意义,与侵略性表型相关.
- 强调需要在NMIBC中进一步调查HS,以改善治疗策略和生物标志物开发.
主要方法:
- 对膀癌中泌尿道癌的当前文献和分类系统的综述.
- 分析NMIBC中HS对临床管理和治疗指南的影响.
- 确定NMIBC中关于HS的研究缺口,特别是关于新疗法和生物标志物的研究.
主要成果:
- 标准的穿尿道诊断在NMIBC中经常错过HS,导致未知的真实患病率.
- 在NMIBC中,HS与瘤的攻击性行为有关,将其归类为 (非常) 高风险.
- 临床指南建议对HSNMIBC进行激进囊切除术,但对膀保存的选择有限.
结论:
- 在NMIBC中的组织学亚型未得到充分承认,但对于风险分层和治疗决策至关重要.
- 目前针对MIBC和NMIBC建立的治疗策略和生物标志物需要在NMIBC的HS背景下进行具体的评估.
- 进一步的研究对于将HS特征纳入NMIBC管理的临床实践至关重要.
更多相关视频
09:243-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
Published on: September 13, 2018
8.9K
11:02Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
21.2K
相关概念视频
01:23Urinary Bladder
520
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
520
01:29Classification of Epithelial Tissues: Stratified Epithelium
9.0K
Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
9.0K