循环节律障碍和内分泌相关的瘤
Christos Savvidis1, Efthymia Kallistrou1, Eleni Kouroglou1
1Department of Endocrinology, Hippocration General Hospital, Athens GR-11527, Greece.
World journal of clinical oncology
|July 29, 2024
概括
循环时钟调节身体的基本功能,它们的干扰与癌症等疾病有关. 了解这些生物节奏为个性化治疗提供了潜力,特别是对于内分泌瘤.
科学领域:
- 时间生物学 时间生物学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 循环时钟由时钟基因控制,维持生理恒常,调节睡眠和清醒周期,新陈代谢和免疫功能.
- 上神核充当中央节拍器,由光同步,而外围时钟则响应诸如食时间等线索.
- 由于生活方式因素导致的循环节障碍与代谢综合征,心血管疾病,感染和癌症有关.
研究的目的:
- 审查昼夜钟与生理过程之间的关系.
- 在代谢障碍和癌症中探索昼夜钟基因的分子机制.
- 要突出昼夜干扰和内分泌瘤之间的特定联系.
主要方法:
- 关于昼夜节律,时钟基因和疾病研究的文献综述.
- 对基因功能的基因机制进行分析. 昼夜钟基因功能.
- 检查流行病学和分子数据,将昼夜干扰与内分泌癌症联系起来.
主要成果:
- 循环节障碍与代谢综合征,心血管疾病,感染和癌症的风险增加有关.
- 特定的内分泌瘤,包括乳腺,卵巢,前列腺和甲状腺癌,与昼夜干扰有关.
- 像PER和CLOCK这样的循环时钟基因会影响瘤的进展,耐药性和癌症的发生.
结论:
- 昼夜节律在癌症的发展和进展中起着至关重要的作用,影响细胞周期,DNA修复,新陈代谢和免疫力.
- 将生物定时整合到医疗保健中可能会导致新的治疗策略,例如内分泌瘤的慢性治疗.
- 需要进一步的研究来阐明详细的昼夜时钟与癌症的联系,为公共卫生干预和个性化医学提供信息.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
01:27Major Hormones and Their Functions
357
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
357
01:19Psychoneuroimmunology: Diabetes and Cancer
27
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
27
01:29The Endocrine System
251
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
251
01:10An Overview of the Endocrine System
8.2K
The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
The endocrine system collaborates...
8.2K
00:46What is the Endocrine System?
414.2K
The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
414.2K