半孔性Fe3O4/SiO2/poly(2-碳基乙烯酸) 复合聚合物颗粒用于pH响应的负载和生物活性分子的有针对性的释放
Most Nusrat Jahan1, Md Ashraful Alam1, Md Mahabur Rahman1,2
1Department of Chemistry, Research Laboratory of Polymer Colloids and Nanomaterials, Rajshahi University Rajshahi 6205 Bangladesh samarhass@yahoo.com hahmad@ru.ac.bd.
RSC advances
|July 29, 2024
概括
这项研究开发了以聚合物 (Fe3O4/SiO2/P(2-CEA)) 涂层的pH响应的磁性中等性二氧化颗粒,用于向药物输送. 这些颗粒在性条件下显示出米素和p-acetamido的受控释放,适用于治疗肠/结肠癌.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 聚合物化学 聚合物化学
背景情况:
- 响应pH的聚合物微球对于有针对性的药物输送有价值.
- 开发具有可控释放性质的新材料对于治疗应用至关重要.
研究的目的:
- 用于制备pH响应的聚合物修饰磁性半孔SiO2颗粒 (Fe3O4/SiO2/P(2-CEA)).
- 研究合成复合材料颗粒的pH依赖性行为和药物释放能力.
主要方法:
- Fe3O4 核心粒子的一溶热合成.
- 用半孔SiO2进行涂层,并对2-碳基乙烯酸酸盐 (2-CEA) 进行种子乳液聚合.
- 使用布鲁努埃尔-埃梅特-特勒 (BET) 分析和pH依赖的染料吸附进行表征.
主要成果:
- Fe3O4/SiO2/P(2-CEA) 复合物颗粒呈现了依赖pH的体积和表面电荷变化.
- 在pH值10.0.0下观察到康明素 (99%) 和p-乙胺基 (46%) 的受控释放.
- 较低,但适合于pH值8.0的药物释放,表明有针对性输送的潜力.
结论:
- 该Fe3O4/SiO2/P(2-CEA) 复合材料作为一个具有pH响应门系统的微囊.
- 该材料对性环境中的药物输送具有前景,例如用于治疗肠/结肠癌.
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