过度的白天小睡会增加非酒精性脂肪性肝病的风险:一个元分析和孟德尔随机化研究
Xiuqi Qiao1,2, Xiaoxia Wang1, Lixin Guo1,2
1Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, People's Republic of China.
白天小睡,尤其是超过30分钟的长时间小睡,与患非酒精性脂肪肝疾病 (NAFLD) 的风险更高有关. 这一发现适用于观察和遗传倾向.
科学领域:
- 肝病学和遗传流行病学
背景情况:
- 观察性研究表明,白天小睡和非酒精性脂肪性肝病 (NAFLD) 之间存在联系.
- 白天小睡和NAFLD之间的因果关系尚不清楚.
研究的目的:
- 调查白天小睡和非酒精性脂肪肝疾病 (NAFLD) 之间的因果关系.
- 综合基因和观察研究的证据.
主要方法:
- 一个双样本的孟德尔随机化 (MR) 分析,使用与白天小睡相关的105个单核酸多态 (SNP).
- 来自英国生物银行关于NAFLD结果研究的观测数据的元分析.
- 网络元分析以评估午睡时间和NAFLD风险之间的关系.
主要成果:
- 分析显示,对于小睡超过30分钟的人来说,NAFLD的风险明显更高 (OR = 1.32,95% CI:1.05至1.66).
- 核磁共振分析表明,日间睡眠时间较长的遗传倾向与NAFLD增加的可能性显著相关 (OR = 2.26,95% CI:1.38至3.73).
结论:
- 白天小睡,特别是超过30分钟的时间,与非酒精性脂肪肝疾病 (NAFLD) 的风险增加有关.
- 研究结果支持习惯性小睡和NAFLD发展之间存在直接的因果关系.
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