鲁金吉杜的可以通过调节肠道微生物群来保护人免受流感病毒感染
Qilin Huang1,2, Guizhen Yang1,2, Chenchen Tang1,2
1The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosecurity, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Heliyon
|July 29, 2024
概括
鲁金吉杜 (Rujin Jiedu) (RJJDD) 通过减少炎症和保持肠道微生物群平衡,可以预防流感肺炎. 这种传统中医药为严重的流感感染提供了潜在的新疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 鲁金 (Rujin Jiedu) (RJJDD) 是一种用于治疗肺炎的传统中医药.
- 它对抗流感病毒感染的疗效尚不清楚.
- 这项研究研究了RJJDD在流感中的抗炎作用和机制.
研究的目的:
- 在小鼠模型中评估RJJDD对A型流感病毒 (IAV) 诱导的肺炎的保护作用.
- 探索RJJDD的潜在抗炎机制.
- 调查RJJDD在流感感染期间对肠道微生物群的影响.
主要方法:
- 小鼠感染了流感病毒,并接受了RJJDD或oseltamivir的治疗.
- 网络药理学被用来预测潜在的治疗途径.
- 使用qRT-PCR和ELISA分析了细胞因子表达.
- 通过16S rDNA测序来评估肠道微生物组成.
主要成果:
- RJJDD证明了对IAV诱导的肺炎的保护作用.
- 网络药理学表明,RJJDD降低了炎症信号通路的调节.
- 实验验证证了肺组织和巨细胞中炎症性细胞因子水平的降低.
- 治疗RJJDD可以预防IAV诱导的肠道失调.
结论:
- 通过调节炎症反应,RJJDD可以预防流感肺炎.
- 维持肠道微生物群的稳态是RJJDD有效性的关键机制.
- RJJDD提出了严重流感的潜在新疗法策略.
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