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肠-大脑轴:一种尖端的方法来准神经系统疾病和潜在的共生应用
Sumel Ashique1, Sourav Mohanto2, Mohammed Gulzar Ahmed2
1Department of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur, 713212, West Bengal, India.
Heliyon
|July 29, 2024
概括
肠-大脑轴将肠道微生物与大脑健康联系起来,影响神经系统疾病. 通过像共生菌这样的干预来调节这个轴,显示出治疗大脑疾病的前景.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 微生物群-肠-大脑轴 (MGBA) 是一个复杂的双向通信系统,连接肠道和大脑.
- 这个轴涉及免疫,内分泌和神经通路,包括迷走神经和下丘脑-垂体-上腺 (HPA) 轴.
研究的目的:
- 探索MGBA在神经疾病 (NDs) 中的作用.
- 调查肠道失调对中枢神经系统健康的影响.
- 评估针对神经疾病的MGBA的治疗潜力.
主要方法:
- 对MGBA通信通路的现有证据的审查.
- 分析肠道失调对神经炎症和微质激活的影响.
- 检查肠道微生物群在神经递质产生和免疫调节中的作用.
主要成果:
- 肠道失调与各种ND相关,包括焦虑,抑郁,自闭症,帕金森病 (PD) 和阿尔茨海默病 (AD).
- 微生物群通过神经炎症和免疫调节 (细胞因子,化学因子) 影响中枢神经系统的健康.
- 协生菌和SCFA在认知功能,减少炎症和中枢神经系统平衡中发挥作用.
结论:
- 在神经系统疾病的发病过程中,MGBA是至关重要的.
- 通过饮食或协生菌向MGBA,为NDs提供了潜在的治疗策略.
- 需要进一步的临床研究来充分阐明和利用MGBA的治疗潜力.
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