扩散性低级质瘤:评估瘤生长的最佳线性测量方法是什么?
Thomas Dos Santos1, Jeremy Deverdun1,2, Thierry Chaptal1,2
1Department of Neuroradiology, Montpellier University Medical Center, Montpellier, France.
Neuro-oncology advances
|July 29, 2024
概括
三维线性方法提供了一种时间效率高,标准化的方法来评估分散的低度质瘤 (LGG) 的生长,在精度和进展检测方面表现优于其他线性测量. 这种方法是例行放射学评估中手动体积测量评估的切实可行的替代方案.
科学领域:
- 神经瘤学神经瘤学
- 放射学 放射学是一门学科.
- 医学成像分析分析 医学成像分析
背景情况:
- 从放射学上评估扩散性低级质瘤 (LGG) 的生长是复杂的,因为瘤的特征如透和扩散边界.
- 目前的视觉评估缺乏客观量化,需要标准化的线性测量规则来准确跟踪LGG演变.
研究的目的:
- 为了比较1D,2D和3D线性测量与手动体积细分的有效性,以评估LGG瘤生长.
- 建立特定于LGG的进展值,并评估线性方法在检测瘤进展中的灵敏度.
主要方法:
- 分析了36名LGG患者和340名MRI扫描.
- 优化的1D,2D和3D线性测量与手动体积细分进行了比较.
- 使用了平均瘤直径 (MTD) 和速度直径扩张 (VDE),并根据RECIST,Macdonald和RANO标准调整了进展值.
主要成果:
- 3D线性方法与手动细分有很强的相关性,并且对于进展检测具有最高的灵敏度.
- MTD显示了可比的结果,而VDE表明小瘤残留的谨慎.
- 更新了LGG特定的门:3D (40%至52%),2D (25%至33%) 和1D (20%至16%).
- 3D方法节省了大约5分钟的时间.
结论:
- 手动体积评估是增长率计算的黄金标准.
- 3D线性方法是LGG常规放射性评估中最节省时间和标准化的替代方案.
- 这种方法为监测LGG进展提供了实用和精确的工具.
相关概念视频
01:23Microbial Growth Measurement: Direct Methods
Direct methods for measuring microbial populations in a culture are essential tools in microbiology, providing quantitative data for various applications. Among these, microscopic counts, plate counts, and serial dilution are widely used techniques, each with unique principles and applications.Microscopic CountsMicroscopic counting involves the use of a Petroff-Hausser chamber, a specialized microscope slide with a grid and defined depth. By observing a liquid culture under a microscope,...
01:27Microbial Growth Measurement: Indirect Methods
Estimating microbial growth is essential for understanding population dynamics and environmental adaptations. Indirect methods provide valuable insights by measuring parameters such as turbidity, metabolic activity, and biomass, enabling efficient and reproducible assessments.During exponential growth, microbial cells scatter light proportionally to their biomass, a principle used in turbidity measurements. About one million cells per milliliter produce detectable scattering, which a...