通过对祖先SARS-CoV-2的综合记忆B细胞抗体进行广泛的萨尔贝科病毒中和
Cyril Planchais1, Ignacio Fernández2,3, Benjamin Chalopin4
1Institut Pasteur, Université Paris Cité, INSERM U1222, Humoral Immunology Unit, 75015 Paris, France.
iScience
|July 29, 2024
概括
从单个个体中克隆的两种广泛中和抗体Cv2.3194和Cv2.3132显示出对SARS-CoV-2变种的持续活性. 它们的组合提供了协同保护,突出了强大的记忆B细胞抗体对进化的病毒的反应.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 结构生物学 结构生物学
背景情况:
- 抗体对抗SARS-CoV-2的防御至关重要,但面临着新出现的病毒变体带来的挑战.
- 随着SARS-CoV-2的不断演变,需要开发广泛中和的抗体来对抗免疫逃逸.
研究的目的:
- 鉴定和描述SARS-CoV-2康复个体内存B细胞中的新型,广泛中和抗体.
- 评估这些抗体对当前和未来的SARS-CoV-2变种的中和能力和潜在协同效应.
主要方法:
- 克隆来自康复期的个人后祖先SARS-CoV-2感染的记忆B细胞.
- 对抗体结合表位和对各种SARS-CoV-2变异的中和活性进行表征,包括Omicron子系.
- 当抗体结合时,对协同中和的评估.
主要成果:
- 鉴定了两种广泛中和抗体:Cv2.3194 (抗RBD,对Omicron活跃到BA.2.86) 和Cv2.3132 (准HR2区域,接近泛撒尔贝病毒活动).
- Cv2.3194和Cv2.3132表现出相互补充的中和简介.
- Cv2.3194和Cv2.3132的组合表现出剂量依赖的协同作用中和.
结论:
- 由祖先SARS-CoV-2感染引起的强大的中和记忆B细胞抗体可以有效地抵消病毒进化和免疫逃脱.
- 鉴定的抗体尾酒,Cv2.3194和Cv2.3132,由于协同活动,显示出对最新的SARS-CoV-2变种进行保护的巨大潜力.
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