母亲RSV疫苗接种和分娩之间的较长间隔增加了胎盘转移效率
medRxiv : the preprint server for health sciences
|July 29, 2024
概括
孕产妇呼吸道同胞性病毒 (RSV) 疫苗接种提供了比自然感染更高的抗体水平. 最佳的时间,至少在分娩前5周,最大限度地将抗体转移到新生儿身上.
科学领域:
- 免疫学 免疫学 免疫学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 呼吸道共囊病毒 (RSV) 对新生儿和婴儿构成重大风险.
- 母亲的RSVpreF疫苗接种已被批准用于怀孕32-36周,以保护婴儿.
- 对抗体转移的最佳孕产妇疫苗定时还没有很好地定义.
研究的目的:
- 评估疫苗接种时妊娠年龄对母亲向新生儿转移抗体的影响.
- 为了比较母体RSV疫苗接种与自然RSV感染的抗体水平.
- 根据从母体疫苗接种到分娩的时间来评估抗体转移效率.
主要方法:
- 对124名接受RSV疫苗的孕妇进行前性队列研究.
- 对抗RSV F和G蛋白质的IgG抗体水平的测量.
- 使用储存样本,比较疫苗接种和自然感染的抗体标位.
- 根据疫苗接种时间对抗体转移比率和婴儿抗体水平的分析.
主要成果:
- 与自然感染相比,母体RSV疫苗接种产生了显著更高的母体和带抗FRSV抗体水平.
- 在分娩前2至4周的接种疫苗显示下带:母体抗体转移比在接种疫苗前5周的比率更高.
- 与早些时候在怀孕期间给予的百日咳疫苗接种相比,转移率也较低.
结论:
- 在经批准的窗口内 (产前≥5周) 较早地给予母亲RSV疫苗,可以优化体外抗体转移.
- 这些发现支持对孕妇提供咨询,以了解早期接种疫苗的好处,以提高新生儿的保护.
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