在螺旋计后诊断慢性阻塞性肺病的性别差异
Alexander T Moffett1,2,3, Scott D Halpern1,2,3,4,5, Gary E Weissman1,2,3,4
1Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
medRxiv : the preprint server for health sciences
|July 29, 2024
概括
女性在慢性阻塞性肺病 (COPD) 诊断的延迟时间比男性更长,即使精神测量测试证实了这种情况. 这表明COPD诊断中持续存在的性别偏见.
科学领域:
- 肺部医学 肺部医学
- 健康差异 在健康上的差异
- 诊断的准确性 诊断的准确性
背景情况:
- 慢性阻塞性肺病 (COPD) 的诊断往往会延迟,女性报告的延迟比男性更频繁.
- 这些诊断延迟的原因尚不清楚.
- 以前的研究表明,诊断中的性别差异可能会在螺旋测量后得到解决.
研究的目的:
- 调查COPD诊断中的基于性别的延迟是否即使在进行了螺旋计后仍然存在.
- 为了比较COPD诊断的时间,在螺旋计后的男性和女性中.
主要方法:
- 使用Optum实验室数据仓库进行回顾性队列研究.
- 包括18岁以上没有先前COPD诊断的患者,以及表现出阻塞的螺旋体检结果 (支气管扩展后FEV1/FVC<0.7).
- 考克斯的比例危险模型用于比较诊断的时间,调整年龄,种族,种族,烟草使用和FEV1/FVC比率.
主要成果:
- 与男性相比,女性在螺旋计后接受COPD诊断的可能性较低 (调整后危险比率[aHR]0.66,95%CI0.50至0.88).
- 这表明女性诊断的延迟在统计学上显著.
结论:
- 在COPD诊断中基于性别的差异仍然存在,即使精神测量结果支持诊断.
- 临床医生不太可能在女性中诊断COPD,强调需要在临床实践中解决性别偏见.
- 这些发现挑战了先前的假设,即螺旋计消除了COPD诊断中的性别差异.
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