具有肝脏恶性瘤的种族群体之间的生存差异
Deng Han1,2, Zhi-Yu Zhang3, Jin-Yan Deng1,2
1Division of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
World journal of gastrointestinal oncology
|July 29, 2024
概括
种族显著影响肝脏恶性瘤的预后. 亚洲患者的存活率更高,而黑人患者的存活率更低,在不同种族群体之间有不同的预后因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 肝脏恶性瘤在不同种族群体中表现出不同的临床和病理特征.
- 了解基于种族的差异对于改善肝癌患者的治疗结果至关重要.
研究的目的:
- 研究种族对肝脏恶性瘤临床病理学特征和预后的影响.
- 为了确定肝癌患者的种族特异性预后因素.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 数据库 (2000-2019) 的数据.
- 分析了123,558名肝脏恶性瘤患者的临床病理特征和生存结果.
- 采用克鲁斯卡尔-瓦利斯试验,单变量和考克斯回归分析来评估预后因素.
主要成果:
- 跨种族群体观察到显著的生存差异:亚洲人 (平均存活12.56个月),黑人 (7.70个月) 和白人 (9.35个月).
- 与黑人 (19%和13%) 和白人 (21%和15%) 患者相比,亚洲患者的3年和5年生存率较高 (29%和22%).
- 预后因素因种族而异,年龄和N阶段对白人患者具有重要意义,收入对亚洲患者没有影响.
结论:
- 与黑人患者相比,亚洲患者对肝脏恶性瘤的预后更好.
- 白人患者的预后受到多种因素的影响,包括年龄和N阶段.
- 种族特异性分析对于理解和管理肝癌差异至关重要.
相关概念视频
Comparing the Survival Analysis of Two or More Groups
168
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
168
Cancer Survival Analysis
336
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
336


