肥胖和饮食独立地影响母亲的免疫力,母亲的肠道微生物群和小鼠的怀孕结果
Lieske Wekema1, Sam Schoenmakers2, Nicole Schenkelaars2
1Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Frontiers in immunology
|July 29, 2024
概括
孕妇的肥胖和饮食在怀孕期间显著改变免疫反应和肠道细菌,影响胎儿和胎盘体重. 在怀孕期间不建议改变饮食;专注于肠道健康的前/益生菌.
科学领域:
- 生殖免疫学 生殖免疫学
- 微生物组研究的研究.
- 孕产妇和胎儿的医学
背景情况:
- 孕产妇肥胖与不良妊娠结果和尚未探索的机制有关.
- 肥胖和饮食影响肠道微生物群,失生症和轻度炎症.
- 了解这些因素对于母亲和后代的健康至关重要.
研究的目的:
- 研究母亲肥胖和饮食对免疫反应的独立和联合影响.
- 探索肠道微生物群变化与怀孕结果之间的关联.
- 评估怀孕期间改变饮食对小鼠的影响.
主要方法:
- 给小鼠提供高脂肪饮食 (HFD) 或低脂肪饮食 (LFD) 以诱导肥胖或保持瘦身.
- 在怀孕期间研究了饮食转换组 (HFD到LFD).
- 分析了免疫细胞子集 (T辅助细胞,单细胞),肠道微生物群 (16SrRNA) 和妊娠结果 (胎儿/胎盘体重).
主要成果:
- 肥胖改变了T辅助细胞子集和单细胞激活,独立于饮食.
- 饮食切换还诱导了特定的免疫细胞和单细胞变化.
- 肥胖和饮食转换都影响了肠道微生物群的组成,与免疫系统的变化相关.
- 肥胖降低胎儿体重;饮食转换降低胎盘体重.
结论:
- 孕产妇的肥胖和饮食独立地影响免疫反应和肠道微生物群的组成.
- 这些变化与不良妊娠结果有关,包括胎儿和胎盘体重降低.
- 在怀孕期间不建议进行饮食干预; 益生菌前/益生菌可能有利于母亲的肠道健康和怀孕结果.
更多相关视频
10:17An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
7.0K
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
1.6K
相关概念视频
01:24Obesity
1.6K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.6K
01:30Development of Human Microbiota
44
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
44
01:22Gut-Brain Axis
99
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
99