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放射性ADME证明了ARV-110的高耐药性,尽管口服生物可用性低

Yifei He1,2, Yuandong Zheng1, Chenggu Zhu3

  • 1Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Journal of medicinal chemistry
|July 29, 2024
PubMed
概括

针对蛋白质溶解的嵌合体 (PROTACs) 显示出有前途的治疗方法. 尽管口服吸收较差,但PROTACs (如巴夫德胺) 显示出更高的疗效,优先考虑目标特异性而不是生物可用性.

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