多发性骨髓瘤的风险调整治疗:更多是否会让它更愉快?
Saurabh Zanwar1, Gliceida M Galarza Fortuna2, Douglas W Sborov2
1Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
British journal of haematology
|July 29, 2024
概括
提出了可移植,高风险多发性髓瘤 (HRMM) 的管理建议. 不断变化的定义和新型疗法需要扩展风险评估,超越传统方法,以获得更好的患者结果.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床实践指南 临床实践指南
背景情况:
- 高风险多发性骨髓瘤 (HRMM) 管理正在随着新的基因组洞察和疗法而发展.
- 传统的风险分层方法可能不足以准确评估HRMM.
- 在HRMM的前线治疗中,正在探索治疗强化策略.
研究的目的:
- 为可移植,高风险多发性骨髓瘤患者提供管理建议.
- 强调需要在HRMM中更新风险评估.
- 讨论新型治疗方法在HRMM中的作用.
主要方法:
- 对HRMM治疗加剧的最近临床试验的审查.
- 在HRMM中分析不断变化的定义和基因组见解.
- 讨论治疗和耐受性方面的挑战.
主要成果:
- 提供了管理可移植HRMM患者的建议.
- 随着HRMM定义的不断变化,需要更广泛的风险评估.
- 新型疗法对于改善HRMM的结果至关重要.
结论:
- 目前的HRMM管理策略需要纳入先进的风险评估.
- 新的治疗方式,包括双特异性抗体和CAR T细胞疗法,对HRMM有希望.
- 解决治疗提供和耐受性挑战对于优化HRMM患者护理至关重要.
相关概念视频
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Bone Marrow Sampling and Transplants
318
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
318


