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和缺乏症在晚期慢性肝病中的患病率和预后值

Nina Dominik^1,2, Lorenz Balcar^1,2, Georg Semmler^1,2

¹Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.

Alimentary pharmacology & therapeutics

|July 29, 2024

概括

和缺乏症在晚期慢性肝病 (ACLD) 中很普遍. 这些必需的微量元素的低水平独立地预测肝脏衰竭和死亡,需要对补充剂进行进一步的研究.

科学领域:

人体生理学中的微量元素代谢.
肝病学和肝脏疾病研究.

背景情况:

和是重要的微量元素,对生理功能至关重要.
在晚期慢性肝病 (ACLD) 中,和缺乏的患病率和预后意义尚不清楚.

研究的目的:

确定ACLD患者中和缺乏症的患病率.
评估/缺乏症和ACLD严重程度之间的关联,包括肝脏相关事件 (LRE).

主要方法:

在309名ACLD患者的血清中测量了和水平.
评估了肝血管压力梯度 (HVPG).
评估了与ACLD严重程度 (MELD,HVPG) 和LRE的关联.

主要成果:

缺和的比例很高 (分别为73%和63%).
较低的和水平与较高的MELD得分,HVPG和疾病严重程度有显著的相关性.
低/水平,以及年龄和MELD,独立预测了LRE.

结论:

在ACLD中,和缺乏是常见的,特别是在严重的病例中.
低血清和水平是肝脏衰竭和肝脏相关死亡率的独立预测因素.
未来的临床试验应该探索和补充在ACLD患者的治疗潜力.

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