第一次精神分裂症的小脑有效连接的改变以及治疗后的长期变化
Xia Wei1,2,3, Hengyi Cao4,5, Chunyan Luo1,2,3
1Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Psychiatry and clinical neurosciences
|July 29, 2024
概括
精神分裂症 (SZ) 涉及改变的大脑连接. 患者从小脑中增加了自下而上的信号,并减少了向小脑的自上而下的信号,这些信号在治疗后部分得到改善.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 大脑皮层功能失联与精神分裂症 (SZ) 有关.
- 了解方向连接对于SZ病理至关重要.
- 以前的研究强调了大脑皮层电路在SZ中的作用.
研究的目的:
- 为了研究SZ患者大脑-皮层定向连接的改变.
- 检查从基线到一年后续的有效连接 (EC) 的变化.
- 将EC变化与症状严重程度和治疗反应联系起来.
主要方法:
- 使用了休息状态功能磁共振成像 (fMRI).
- 用九个小脑功能系统作为种子进行了格兰杰因果分析.
- 包括180名先前未服用药物的第一期SZ患者和166名健康对照 (HCs);54名SZ患者在1年后被重新评估.
主要成果:
- 第一次SZ患者表现出自下而上的EC增加 (小脑到大脑) 和自上而下的EC减少 (大脑到小脑).
- 受到影响的特定途径包括小脑系统到角旋转和额头旋转 (自下而上),以及旋转/脑膜到小脑语言系统 (自上而下).
- 经过一年的抗精神病治疗后,自上而下的EC预测部分恢复并与症状缓解有积极的相关性.
结论:
- 在急性SZ中降低自上而下的EC可能是与症状和药物相关的状态依赖性变化.
- 增加的自下而上的EC可能代表精神分裂症的持续性病理特征.
- 这些发现为SZ的神经生物学机制和治疗效果提供了洞察力.
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