相关实验视频

Updated: Jun 15, 2026

Using CRISPR/Cas9 Gene Editing to Investigate the Oncogenic Activity of Mutant Calreticulin in Cytokine Dependent Hematopoietic Cells
10:21

Using CRISPR/Cas9 Gene Editing to Investigate the Oncogenic Activity of Mutant Calreticulin in Cytokine Dependent Hematopoietic Cells

Published on: January 5, 2018

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一个全基因组的CRISPR/Cas9屏幕确定了calreticulin作为ATF6α的选择性抑制剂

Joanne Tung1, Lei Huang1, Ginto George1

  • 1Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.

eLife
|July 29, 2024
PubMed
概括

卡莱蒂库林 (CRT) 作为激活转录因子6α (ATF6α) 信号的内细胞网膜 (ER) 抑制剂. 这一发现揭示了展开蛋白质反应 (UPR) 的新调节机制.

关键词:
在ATF6中,这些细胞是CHO-K1细胞.在CRT中,CRT可以在CRT中使用.通过UPR进行全日制检查.卡尔雷蒂库林是一种卡尔雷蒂库林.细胞生物学 细胞生物学细胞内膜网膜的内oplasmic网膜.在全基因组的CRISPR/Cas9屏幕上.不折叠的蛋白质反应反应

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