Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Parametric Survival Analysis: Weibull and Exponential Methods01:14

Parametric Survival Analysis: Weibull and Exponential Methods

394
Parametric survival analysis models survival data by assuming a specific probability distribution for the time until an event occurs. The Weibull and exponential distributions are two of the most commonly used methods in this context, due to their versatility and relatively straightforward application.
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
394
Introduction To Survival Analysis01:18

Introduction To Survival Analysis

203
Survival analysis is a statistical method used to study time-to-event data, where the "event" might represent outcomes like death, disease relapse, system failure, or recovery. A unique feature of survival data is censoring, which occurs when the event of interest has not been observed for some individuals during the study period. This requires specialized techniques to handle incomplete data effectively.
The primary goal of survival analysis is to estimate survival time—the time...
203
Cancer Survival Analysis01:21

Cancer Survival Analysis

336
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
336
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

35
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
35
Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

168
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
168
Statistical Methods for Analyzing Epidemiological Data01:25

Statistical Methods for Analyzing Epidemiological Data

342
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
342

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Dose-Finding Design for Drug Combinations Using a Bayesian 4 Parameter Logistic Model With Penalised D-Optimality.

Pharmaceutical statistics·2026
Same author

Multivariate Bayesian Dynamic Borrowing for Repeated Measures Data With Application to External Control Arms in Open-Label Extension Studies.

Biometrical journal. Biometrische Zeitschrift·2025
Same author

Minimum effective low dose of antithymocyte globulin in people aged 5-25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial.

Lancet (London, England)·2025
Same author

Using Win Odds to Improve Commit-to-Phase-3 Decision-Making in Oncology.

Statistics in medicine·2025
Same author

Calculations involving the multivariate normal and multivariate t distributions with and without truncation.

The Stata journal·2024
Same author

A personalized and systematically designed adherence intervention improves photoprotection in adults with xeroderma pigmentosum (XP): results of the XPAND randomized controlled trial.

The British journal of dermatology·2024

相关实验视频

Updated: Jun 18, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.1K

有效的研究设计和分析使用分数多项式的纵向剂量反应数据.

Benjamin F Hartley1, Dave Lunn2, Adrian P Mander2

  • 1Veramed Ltd., Twickenham, UK.

Pharmaceutical statistics
|July 29, 2024
PubMed
概括

在连续时间剂量反应模型中使用纵向数据显著提高了估计效率. 这种方法,使用分数多项式,可以比单个时间点模型减少高达55%的样本大小.

科学领域:

  • 药学指标 (Pharmacometrics) 是一个指标.
  • 生物统计学 生物统计学
  • 药物开发 药物开发

背景情况:

  • 准确的剂量反应表征对于药物开发至关重要.
  • 传统模型通常依赖于单个时间点的数据,这可能会限制效率.

研究的目的:

  • 为了比较不同剂量反应研究设计的效率.
  • 为了证明在连续时间剂量反应模型中使用纵向数据的好处.

主要方法:

  • 应用最佳设计理论来比较研究设计.
  • 开发和分析连续时间剂量反应模型,包括纵向数据.
  • 使用分数多项式来灵活建模重复测量.

主要成果:

  • 与单个时间点模型相比,连续时间模型中的纵向数据大大提高了估计效率.
  • 效率增长范围为1.43至2.22倍,相当于特定模型的样本大小减少30%-55%.
  • 分数多项式模型提供了模拟错误规范的稳定性,同时保持了效率的提高.

结论:

  • 将纵向数据纳入连续时间剂量反应模型是非常有效的.
关键词:
在C效率方面,C效率是:D-效率是指D的效率.埃马克斯模型模型渔民信息矩阵临床试验的设计进行中期分析分析.纵向建模 纵向建模 纵向建模最低有效剂量的最低有效剂量.

更多相关视频

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
20:24

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

Published on: January 31, 2014

16.5K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.2K

相关实验视频

Last Updated: Jun 18, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.1K
Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
20:24

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

Published on: January 31, 2014

16.5K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.2K
  • 分数多项式模型为剂量反应特征提供了一种灵活而强大的方法.
  • 这些方法对于药物开发中的中间和最终分析是有价值的.