营养不良的严重程度预测了酒精性肝炎的临床结果:来自国家数据的证据
Ali Jaan1, Iyiad Alabdul Razzak2, Ammad Javaid Chaudhary3
1Department of Internal Medicine, Rochester General Hospital, NY, USA.
Journal of the American Nutrition Association
|July 29, 2024
概括
营养不良显著恶化了酒精性肝炎 (AH) 患者的结果,增加了死亡率和并发症. 解决营养状况对于改善AH的预后至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
- 营养科学 营养科学
背景情况:
- 酒精性肝炎 (AH) 是一种严重的酒精性肝病 (ALD).
- 营养不良是ALD的常见并发症,随着疾病的进展而恶化.
- 营养不良严重程度对AH临床结果的影响需要进一步调查.
研究的目的:
- 为了研究营养不良严重程度和临床结果之间的关联,在患者住院治疗AH.
- 分析不同程度的营养不良与死亡率,并发症和卫生保健资源利用率之间的相关性.
主要方法:
- 从2016-2020年国家再入院数据库 (NRD) 中回顾性分析入院的成人患者.
- 根据营养不良的严重程度对AH患者的分类 (轻度至中度,重度,未指明).
- 多变量回归分析以比较结果,包括住院死亡率,败血性休克,血管压缩剂使用,机械呼吸,ICU入院,肝脏并发症和资源利用.
主要成果:
- 在82,367名AH患者中,有19%的人营养不良.
- 住院死亡率随着营养不良的严重程度而增加 (轻度至中度的aOR为1.62,重度为3.14).
- 营养不良与感染性休克的更高几率相关,血管压缩剂的要求,机械通风,ICU入院,肝脏并发症和医疗资源利用率增加.
结论:
- 营养不良是AH患者中普遍存在的并发症,与增加的死亡率和各种不良结果直接相关.
- 营养状况在AH预后中起着至关重要的作用.
- 有效的营养不良管理对于改善患者的治疗结果和降低 AH 中的医疗保健成本至关重要.
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