诺基诺在患有癌症的儿童中的预防:一个赞成/反对的讨论
Eleana Vasileiadi1, Kevin M Lloyd2, Brian T Fisher1,3
1Division of Infectious Disease, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Journal of the Pediatric Infectious Diseases Society
|July 29, 2024
概括
在儿科白血病患者的诺基诺预防有相互矛盾的建议. 有证据表明,降低发烧和细菌血症有好处,但抗生素耐药性的风险需要仔细考虑.
科学领域:
- 儿科瘤学 儿科瘤学
- 传染病管理 传染病管理
- 临床实践指南 临床实践指南
背景情况:
- 关于在儿科瘤学中使用诺基诺的预防措施,存在相互矛盾的建议.
- 国际指导方针对白血病患者建议使用利沃素预防,以减少发烧和细菌血症.
- 欧洲的指导方针建议不要使用勒沃素,因为人们担心抗生素耐药性.
研究的目的:
- 讨论在儿童白血病患者中使用诺基诺预防的细微决定.
- 根据已发表的证据,审查levofloxacin预防的风险和益处.
- 为了确定知识差距,以优化在儿童癌症患者中使用诺基诺.
主要方法:
- 审查现有的儿科临床实践指南.
- 对levofloxacin预防风险和益处的已发表证据的分析.
- 讨论抗生素耐药性的问题.
主要成果:
- 在儿科白血病患者中,利沃素预防可能会降低发烧和细菌病.
- 人们对诺基诺和其他抗生素耐药性增加存在担忧.
- 该决定涉及平衡感染预防与抗菌药物管理.
结论:
- 在儿科瘤学中使用勒沃素预防需要仔细考虑个体患者的风险和抗药性潜力.
- 需要进一步的研究,以优化在免疫功能低下的儿科患者群体中使用诺基诺.
- 在抗微生物预防策略中,平衡有效性和安全性至关重要.
相关概念视频
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Radiological Investigation I: X-ray and CT
219
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
219
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Imaging Studies for Cardiovascular System III: X-Ray
164
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
164


