相关实验视频
Updated: Jun 18, 2025

06:09
Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
11.9K
在接受放射治疗的宫癌患者血清细胞间粘附分子1的临床变化
Lina Song1, Yali Gao2, Zhicong Wang2
1Department of Radiation Therapy, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, 061000, Hebei, China. songlinasonglina@126.com.
Japanese journal of radiology
|July 29, 2024
概括
可溶性细胞内粘附分子-1 (sICAM-1) 可以预测宫癌的发生和预后. 放射治疗后sICAM-1水平降低表明宫癌患者的治疗成功和更好的生存结果.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 放射治疗研究 放射治疗研究
背景情况:
- 在宫癌患者和复发患者中观察到可溶性细胞内粘附分子-1 (sICAM-1) 的水平升高.
- 在宫癌的放射治疗后,sICAM-1的动态变化和预后影响仍然未被描述.
研究的目的:
- 调查sICAM-1对宫癌发生的预测价值.
- 分析sICAM-1水平与临床病理之间的关联.
- 评估放射治疗后sICAM-1动态与患者预后之间的关系.
主要方法:
- 与酶相关的免疫吸收试验 (ELISA) 用于测量sICAM-1水平.
- 接收器运行特征 (ROC) 分析评估了预测价值.
- 费舍尔的精确测试和卡普兰-梅尔曲线分析了与临床因素和生存的关联.
主要成果:
- 宫癌患者的sICAM-1水平显著增加,预测疾病的发生.
- sICAM-1表达与瘤大小,分化和放射治疗反应相关.
- 放射治疗后降低sICAM-1预测完全缓解,而升高水平表明预后不佳和生存时间缩短.
结论:
- sICAM-1 作为宫癌发生的预测生物标志物.
- sICAM-1水平及其放射治疗后的轨迹与宫癌患者的预后有显著的关联.
相关概念视频
Intracellular Signaling Affects Focal Adhesions
2.6K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
2.6K
Immunoglobulin-like Cell Adhesion Molecules
3.2K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.2K

