[在分泌管疾病中,结肠肌肉组织的病理变化]
A K Konyukova1, L M Mikhaleva1,2,3, M A Kozlova1
1Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery, Moscow, Russia.
Arkhiv patologii
|July 29, 2024
概括
结肠分歧性疾病 (DD) 影响了许多人,复杂的病例带来了风险. 大肠肌肉连接组织增加可能预测DD并发症,有助于预防策略.
科学领域:
- 胃肠病学 胃肠病学
- 结肠直肠手术 结肠直肠手术
- 病理学 病理学 病理学
背景情况:
- 结肠管疾病 (DD) 是一种普遍存在的疾病,具有显著的发病率和死亡率.
- 复杂的DD发生在12-15%的患者中,但缺乏预测算法.
- 目前对复杂DD的形态预测因子的理解需要进一步调查.
研究的目的:
- 为了确定复杂的结肠分歧性疾病 (DD) 的形态预测因素.
- 为了比较DD患者和对照患者的临床数据和结肠肌肉组织特征.
- 为了确定DD进展的潜在诊断标记.
主要方法:
- 对68名接受左侧半球切除术的患者的临床数据进行比较分析.
- 结肠肌肉的病态形态和超结构检查.
- 从患有复杂的DD,无复杂的DD和没有分泌器的患者手术材料的分析.
主要成果:
- 结肠分泌管疾病 (DD) 在男性比女性年轻时出现.
- 结肠肌肉中的纤维化在复杂的DD (15%) 与无并发症的DD (3%) 相比是5倍.
- 与对照组相比,复杂DD的结合组织积累是复杂DD的50倍 (0.3%).
结论:
- 结肠肌肉纤维化增加是复杂DD的重要预测因素.
- 年龄和性别影响DD的呈现.
- 结肠肌肉的形态分析为DD并发症预测提供了潜在的可能性.
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