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结果在下大结出血研究中的测量结果

Elena Sagues¹, Andres Gudino¹, Carlos Dier¹

¹Department of Neurology, University of Iowa, 200, Hawkins Drive, Iowa City, IA, USA.

Translational stroke research

|July 29, 2024

概括

标准化结局尺度对于亚关节下出血 (SAH) 研究至关重要,以有效评估新疗法. 本综述建议使用特定的尺度来评估SAH患者的神经,功能,认知和生活质量方面的结果.

科学领域:

神经学神经学
临床研究方法论临床研究方法论

背景情况:

副arachnoid出血 (SAH) 继续有很高的发病率,尽管在急性护理的进步.
标准化结果评估对于评估SAH研究中的新型治疗干预措施至关重要.

研究的目的:

提供SAH中常用的结果尺度和临床终点的全面审查.
为这些评估工具的应用和预后准确性提供建议.

主要方法:

在下大脑下出血评估中使用的流行度表和临床结果的审查.
对尺度应用和预后准确性的建议进行分析.

主要成果:

建议对症状性血管和延迟脑缺血等病理生理结果使用标准化术语.
临床严重程度尺度 (例如,世界神经外科协会联合会,修改后的费舍尔) 应该被整合到试验中.
修改后的兰金尺度和格拉斯哥结果尺度-扩展分别用于功能和更广泛的社会/行为评估.
经常被忽视的认知和行为结果需要使用诸如蒙特利尔认知评估和心理库存等工具进行全面评估.

结论:

建议在SAH研究中对病理生理结果进行标准化报告,并整合临床严重程度等级.
适当选择和应用结果尺度,包括认知,行为和生活质量评估的结果,对于全面的SAH患者评估至关重要.
避免分数二分化对于保存有价值的患者数据和提高预后准确性至关重要.

关键词:

延迟的大脑缺血症延迟的大脑缺血发生出血发生出血措施措施结果的结果.副arachnoid 关节下的一个关节血管是因为血管.

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