在Salsola collina中发现了一种senomorphlytic的三种药物组合,可以延迟衰老的表型并延长健康寿命
Jiqun Wang1, Wenwen Liu2, Yunyuan Huang3
1State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|July 29, 2024
概括
来自Salsola collina (JM10001) 的植物提取物及其衍生物 (JM10101) 在模型生物中延长寿命和健康寿命. 这些化合物有望通过调节衰老细胞来开发新的抗衰老疗法.
科学领域:
- 老年病学和药理学
- 自然产品化学 自然产品化学
- 分子生物学分子生物学
背景情况:
- 衰老是一个复杂的过程,药物干预的目标是安全性和有效性.
- 自然产品为发现新型治疗剂提供了丰富的来源.
- 来自中国云南省的植物提取物的图书馆被选定为抗衰老研究.
研究的目的:
- 识别和描述具有抗衰老功能的天然产品.
- 阐明已识别的化合物的抗衰老作用背后的分子机制.
- 在老化模型中评估这些化合物的治疗潜力.
主要方法:
- 在C. elegans中选植物提取物库,以延长寿命和健康寿命.
- 网络药理学分析以确定关键信号通路 (例如,p53).
- 使用老化加速小鼠和自然老化的小鼠进行体内研究,以评估疗效.
- 化合物的形和解活性的表征.
主要成果:
- 萨尔索拉·科利纳提取物 (JM10001) 显著提高了C. elegans的寿命和健康期.
- 鉴定出p53信号通路是JM10001抗衰老作用的关键调解者.
- 一种由三个成分组成的成分 (JM10101) 保持了JM10001.1.延长寿命的活性.
- 在小鼠模型中,JM10001和JM10101都减轻了衰老症状.
- 与JM10001.1.相比,JM10101表现出优越的老化和老化功能.
结论:
- 萨尔索拉·科利纳提取物及其衍生品JM10101是强大的天然抗衰老剂.
- JM10101在调节衰老细胞方面表现出双重作用,提供了一个有前途的治疗策略.
- 这些发现支持基于天然产品的组合抗衰老药物的合理开发.
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